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HIV Disease: Cotton Wool Spots These microinfarcts of the retina, which occur in many diseases, are common findings even in the early stages of HIV disease. They reflect antigen-antibody plugs rather than infection, although cytomegalovirus retinitis, a finding in advanced HIV disease, starts with cotton wool spots. They do not interfere with vision.
What to do?Cotton wool spots are a marker for HIV disease. If the patient has very low CD4 counts, beware that the cotton wool spots are a precursor of cytomegalovirus retinitis. The patient must be reexamined within days to verify lack of progression.
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 An interactive teaching and assessment program on vision care
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